The first Bischler-Napieralski cyclization in a room temperature ionic liquid

Title: The first Bischler-Napieralski cyclization in a room temperature ionic liquid
Creator: Judeh, Zaher M. A.; Ching, Chi Bun; Bu, Jie; McCluskey, Adam
Relation: Tetrahedron Letters Vol. 43, Issue 29, p. 5089-5091
Publisher Link: http://dx.doi.org/10.1016/S0040-4039(02)00998-X
Publisher: Elsevier Science Ltd.
Resource Type: journal article
Date: 2002
Description: We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF₆), as an environmentally benign solvent for the preparation of isoquinoline derivatives through Bischler–Napieralski cyclization under mild conditions with excellent purity and yields. The role of HF as a catalyst in the reaction was also investigated. The effectiveness of the ionic liquid [bmim]PF₆ as a solvent for the Bischler–Napieralski cyclization was examined for the preparation of isoquinoline derivatives.
Subject: ionic liquids; isoquinolines; Bischler–Napieralski cyclization
Identifier: http://hdl.handle.net/1959.13/33857
Identifier: uon:3325
Identifier: ISSN:0040-4039
Language: eng
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